Pharmacokinetic parameters for the disposition of gemfibrozil in the rat isolated perfused liver after a bolus administration of GG in the absence (control) and presence of acetaminophen (A), acetaminophen glucuronide (AG), and clofibric acid (CFA)
| Parameter | Control | A | AG | CFA |
|---|---|---|---|---|
| AUCg | 33.3 ± 5.1 | 26.7 ± 7.9 | 25.4 ± 10.6 | 24.3 ± 7.9 |
| AUCg,unb | 0.70 ± 0.11 | 0.36 ± 0.11 | 0.63 ± 0.26 | 1.34 ± 0.44 |
AUCg and AUCg,unb denote the area under the perfusate concentration versus time curve from 0 to 90 min for total and unbound gemfibrozil, respectively.
P > .05 for all treatment groups compared with control values.