Pharmacokinetic parameters for the disposition of GG in the rat isolated perfused liver in the absence (control) and presence of acetaminophen (A), acetaminophen glucuronide (AG), and clofibric acid (CFA)
| Parameter | Control | A | AG | CFA |
|---|---|---|---|---|
| CL (ml/min) | 10.4 ± 1.4 | 11.3 ± 1.7 | 12.2 ± 2.7 | 14.8 ± 1.72-150 |
| t 1/2 (min) | 22.5 ± 4.4 | 22.3 ± 8.0 | 18.5 ± 3.3 | 17.0 ± 2.0 |
| E | 0.346 ± 0.046 | 0.376 ± 0.056 | 0.407 ± 0.088 | 0.493 ± 0.0562-150 |
| CLint,app (ml/min) | 94.1 ± 17.9 | 126.1 ± 31.8 | 144.4 ± 60.3 | 187.0 ± 40.72-150 |
| t 1/2,bile (min) | 30.9 ± 4.9 | 28.1 ± 4.8 | 29.1 ± 10.2 | 21.1 ± 2.32-150 |
| BGG (% Dose) | 72.8 ± 10.9 | 74.5 ± 15.6 | 68.9 ± 9.9 | 74.5 ± 9.8 |
| [GG]LIVER (nmol/g tissue) | 3.40 ± 0.64 | 2.57 ± 1.01 | 2.95 ± 1.29 | 1.82 ± 0.142-150 |
| [GG]LIVER/PERFUSATE | 35.0 ± 22.5 | 26.6 ± 26.0 | 46.8 ± 21.2 | 49.4 ± 19.22-a |
| [GG]LIVER/PERFUSATE(unb) | 204.6 ± 131.5 | 237.5 ± 155.8 | 311.4 ± 140.9 | 310.2 ± 120.6 |
| [GG]BILE/LIVER | 89.6 ± 17.6 | 108.8 ± 24.3 | 101.1 ± 24.1 | 85.6 ± 26.9 |
[GG]LIVER, intrahepatic concentration of GG at 90 min; [GG]LIVER/PERFUSATE and [GG]LIVER/PERFUSATE(unb), liver to total perfusate and unbound perfusate concentration ratios, respectively, of GG; [GG]BILE/LIVER, bile to liver concentration ratio of GG.
↵2-a Perfusate GG concentrations at 90 min were extrapolated from the last measured concentration multiplied by e(−kt), where k is the elimination rate constant and t is the time difference between the last measured concentration and the end of the perfusion.
↵2-150 P < .05 compared with the control value.