Pharmacokinetic assessment of SB-222200 after i.v. or p.o. administration to the rat
| i.v. Values (Average) | p.o. Values (Average) | |
|---|---|---|
| Dose (mg/kg) | 2.5 | 10 |
| Cmax(ng/ml) | NA | 427 ± 232 |
| T max(min) | NA | 240 (median) |
| AUC (0–inf, μg/ml · min) | 36, 58 (47) | 93.5 ± 42.6 |
| CLp (ml/min/kg) | 43, 69 (56) | 122 ± 52 |
| t 1/2 (min or h) | 2.4, 1.5 (1.9) min | 2.1 ± 0.4 h |
| F (%) | N.A. | 46 ± 19 |
Values are given as the mean ± S.E.M. for the results of p.o. studies (n = 3) and as the individual values and average (given in parentheses) of the results of i.v. studies (n = 2).
CLp, plasma clearance; AUC, area under the plasma concentration vs. time curve; Cmax, maximum plasma concentration; Tmax, time at which maximum concentration was observed; t1/2, apparent terminal half-life; F, bioavailability; N.A., not applicable.