Effects of antisense oligonucleotides on magnitude and electrophysiological characteristics of hSkM1 Na+ currents recorded from HEK-293 cells
| Condition | INa, max | Inflection Point of m3∞ Curve | Inflection Point of h∞ Curve |
|---|---|---|---|
| nA | mV | ||
| Control | −6.5 ± 1.0 (14) | −26.9 ± 2.7 (15) | −72.9 ± 1.8 (12) |
| 3866asen, fluorescent cells | −2.4 ± 0.52-150 (11) | −26.5 ± 2.7 (11) | −76.7 ± 3.5 (11) |
| 3866sen, fluorescent cells | −8.4 ± 1.6 (10) | −36.9 ± 3.1 (10) | −72.4 ± 1.9 (10) |
| 3866asen, nonfluorescent cells | −8.0 ± 1.5 (8) | −31.6 ± 1.9 (8) | −71.6 ± 1.4 (6) |
| 3886sen, nonfluorescent cells | −5.9 ± 0.8 (11) | −26.3 ± 2.2 (10) | −70.3 ± 1.6 (10) |
The number of tested cells is given in parentheses.
↵2-150 Significantly different from the following groups: control, 3866sen, fluorescent cells and 3866asen, nonfluorescent cells,P < .05, Kruskal-Wallis nonparametric ANOVA test (mean values ± S.E.M. given for all data).