Pharmacokinetic parameter estimates of (−)-M1
| Parameter | Estimate | Interanimal Variability |
|---|---|---|
| V c(l) | 0.170 (0.08) | N.E. |
| V T (l) | 0.563 (0.12) | 39 (0.45) |
| Cld (l min−1) | 0.034 (0.14) | 50 (0.46) |
| Cl (l min−1) | 0.031 (0.07) | 15 (0.36) |
Estimates of interanimal variability are expressed as coefficients of variation (%). Precision of the estimates is expressed as relative standard error in parenthesis. Relative standard error is standard error divided by the parameter estimate.
Vc, initial volume of distribution;VT, apparent volume of distribution of the peripheral compartment; Cld, intercompartmental clearance; N.E., not estimated in the model.