Effect of bupropion pretreatment on different pharmacological measures after s.c. administration in mice
| Measure | Pretreatment Dose1-a | Response |
|---|---|---|
| A) Body temperature | Δt°C (mean ± S.E.) | |
| Saline | −0.3 ± 0.2 | |
| Bupropion (10) | −5.2 ± 0.2 | |
| B) Seizure activity | % Seizures (mean) | |
| Saline | 0 | |
| Bupropion (10) | 0 | |
| C) Tail-flick test | % MPE (mean ± S.E.) | |
| Saline | 6 ± 2 | |
| Bupropion (25) | 5 ± 2 | |
| D) Hot-plate test | %MPE (mean ± S.E.) | |
| Saline | 8 ± 2 | |
| Bupropion (10) | 10 ± 6 | |
| E) Spontaneous activity | Interrupts (mean ± S.E.) | |
| Saline | 1877 ± 345 | |
| Bupropion (25) | 2241 ± 309 |
↵1-a Doses are expressed as milligrams per kilogram in parentheses.