Table 3

IP3 levels in rat brain 14 days after ADX and simultaneous implantation of CORT pellets (50 or 100 mg) into ADX rats

IP3Levels
CortexHippocampusCerebellum
pmol/mg protein
Sham-operated64.8  ± 11.275.6  ± 12.490.4  ± 17.5
ADX103  ± 11.73-160 3-151 110.2  ± 9.13-160 3-151 135.2  ± 10.23-160 3-151
ADX + CORT (50 mg)81.2  ± 9.73-150 3-164 91.6  ± 8.43-150 3-164 110.6  ± 11.43-150 3-164
ADX + CORT (100 mg)59.8  ± 8.53-160 3-164 72.5  ± 7.63-160 3-164 95.3  ± 9.83-160 3-164

Values are expressed as the mean ± S.D. n = 6 in each group.

  • ↵3-151  As compared with sham;

  • ↵3-164  as compared with ADX;

  • ↵3-150  P < .01,

  • ↵3-160  P< .001.