Table 2

Motor toxicity (TD₅₀), protective potency (ED₅₀), and PI of drugs against cocaine-induced lethality

	Chlormethiazole	Clonazepam	Diazepam
TD₅₀	156 (133–182)	1.06 (0.50–2.38)	2.80 (1.24–6.31)
ED₅₀	21.8 (11.1–41.54)	0.84 (0.30–2.38)	2.40 (0.88–6.54)
PI	7.16	1.26	1.17

TD₅₀ values of clonazepam and diazepam are from Witkin et al. (1999). The remaining values (with 95% CL in parentheses) were calculated from the dose-effect functions as shown in Figs. 2(TD₅₀ value of chlormethiazole) and 6 (all ED₅₀values). ED₅₀ and TD₅₀ values represent a dose of a drug (mg/kg) predicted to produce an effect in 50% of the mice tested. PI values represent a ratio of the TD₅₀ and ED₅₀ values of a drug.