Quantitative image analysis glomerular morphometry parameters in different animal groups investigated
| WKY (n = 10) | SHR (n = 10) | SHR + LER 0.5 (n = 7) | SHR + LER 2.5 (n = 8) | SHR + MAN (n = 7) | SHR + NIC (n = 8) | SHR + HYD (n = 8) | |
|---|---|---|---|---|---|---|---|
| Cortex volume (mm3) | 538 ± 31 | 420 ± 232-a | 423 ± 302-a | 428 ± 332-a | 426 ± 282-a | 425 ± 352-a | 422 ± 312-a |
| Number of glomeruli (× 103) | 30.1 ± 2.1 | 25.3 ± 1.92-a | 25.6 ± 1.32-a | 25.6 ± 1.52-a | 25.8 ± 2.12-a | 25.4 ± 1.72-a | 25.4 ± 2.22-a |
| Total glomerular volume (mm3) | 21.4 ± 0.2 | 23.8 ± 0.32-a | 22.6 ± 0.22-a 2-b | 19.4 ± 0.32-a 2-b 2-c | 19.2 ± 0.22-a 2-b 2-c | 20.3 ± 0.22-a 2-b 2-c 2-d 2-e | 22.5 ± 0.32-a 2-b 2-d 2-e 2-f |
| Volume of glomerular tuft (103 μm3) | 711.7 ± 16.1 | 915.5 ± 23.22-a | 843.6 ± 16.62-a 2-b | 730.1 ± 22.02-b 2-c | 736.1 ± 30.12-b 2-c | 798.3 ± 33.82-a 2-b 2-c 2-d 2-e | 846.8 ± 15.82-a 2-b 2-d 2-e 2-f |
| Mesangial cell nuclei/volume glomerular tuft | 85.0 ± 6.3 | 128.4 ± 9.62-a | 104.3 ± 8.52-a 2-b | 86.4 ± 6.32-b 2-c | 86.9 ± 7.32-b 2-c | 87.2 ± 6.12-b 2-c 2-d | 98.2 ± 6.12-a 2-b 2-c 2-d 2-e 2-f |
Data are the mean ± S.E. Details on morphometric analysis protocol are reported under Materials and Methods. For the significance of abbreviations see Table 1.