Inhibitory effects of T-1032 and sildenafil on six canine PDE isozymes
| Compounds | IC50 | |||||
|---|---|---|---|---|---|---|
| PDE V | PDE I | PDE II | PDE III | PDE IV | PDE VI | |
| μM | ||||||
| T-1032 | 0.001 | 3 | 10 | >100 | 3 | 0.03 |
| Sildenafil | 0.004 | 0.3 | 43 | >100 | 11 | 0.03 |
PDE I, IV, and V were isolated from the lung and PDE III was from the heart. PDE II and VI were prepared from the adrenal gland and retinas, respectively. All data were cited from the previous study (Kotera et al., 2000).