The effect of i.v. (+)-apomorphine on the decrease in the number of spontaneously active A10 DA neurons produced by the repeated p.o. administration of SB-277011-A
| A10 DA Cells/Track | ||
|---|---|---|
| Before i.v. APO | After i.v. APO | |
| Dose of SB-277011-A (mg/kg) | ||
| 1 | 0.46 ± 0.08 (10) | 0.60 ± 0.07 (6) |
| 3 | 0.49 ± 0.09 (10) | 0.54 ± 0.07 (7) |
| 10 | 0.84 ± 0.13 (10) | 0.51 ± 0.07 (7)8-a |
In each experiment, the number of spontaneously active DA neurons was determined in 10 stereotaxically defined tracks following the administration of SB-277011-A for 21 days. Immediately following this, animals received 50 μg/kg i.v. (+)-apomorphine, and the number of spontaneously active A10 DA neurons was determined in 5 additional stereotaxically defined tracks. APO, (+)-apomorphine. Each value represents the mean number of spontaneously active A10 DA neurons detected per electrode descent ± S.E. The numbers in parentheses represent the number of animals examined.
APO, (+)-apomorphine.
↵8-a Significantly less than the 10-mg/kg dose before i.v. (+)-apomorphine, P < .01, Student's t test.