Parameter | Control | SB (1 mg/kg) | SB (3 mg/kg) | SB (10 mg/kg) | ||||
---|---|---|---|---|---|---|---|---|
A9 | A10 | A9 | A10 | A9 | A10 | A9 | A10 | |
Spikes/burst | 2.1 ± 0.24-a | 2.9 ± 0.3 | 3.1 ± 0.34-b | 3.1 ± 0.3 | 2.3 ± 0.3 | 2.2 ± 0.34-c | 2.1 ± 0.3 | 2.4 ± 0.24-c |
Interspike interval (ms) | 285 ± 174-a | 226 ± 14 | 242 ± 20 | 214 ± 19 | 220 ± 15 | 299 ± 244-d | 239 ± 23 | 286 ± 154-e |
Percentage of events as bursts | 164-f | 30 | 28 | 28 | 16 | 19 | 17 | 25 |
Number of bursts | 164-f | 234-g | 17 | 194-h | 11 | 104-i | 11 | 13 |
Coefficient of variation | 50 ± 34-a | 63 ± 5 | 55 ± 4 | 60 ± 4 | 46 ± 5 | 46 ± 4 | 45 ± 3 | 60 ± 5 |
Percentage of neurons bursting | 34 | 53 | 594-j | 61 | 41 | 334-k | 39 | 51 |
Number of cells | 40 | 40 | 39 | 38 | 37 | 36 | 36 | 39 |
SB, SB-277011-A.
↵4-a Each value represents the mean ± S.E.
↵4-b Significantly less than A9 control and the A9 10-mg/kg dose, P < .05, ANOVA and Student-Newman-Keul's test.
↵4-c Significantly less than A10, 1-mg/kg dose, P < .05, ANOVA and Student-Newman-Keul's test.
↵4-d Significantly greater than A10 control and 1-mg/kg dose, P < .05, ANOVA and Student-Newman-Keul's test.
↵4-e Significantly greater than A10, 1-mg/kg dose, P < .05, ANOVA and Student-Newman-Keul's test.
↵4-f Each value represents the mean.
↵4-g Significantly greater than A10, 3- and 10-mg/kg doses, P < .01 and .05, Kruskal-Wallis ANOVA and Student-Newman-Keul's test.
↵4-h Significantly greater than A10, 3-mg/kg dose, P < .01.
↵4-i Significantly less than A10, 10-mg/kg dose, P < .05, Kruskal-Wallis ANOVA and Student-Newman-Keul's test.
↵4-j Significantly less than A9 control, 1-, 3-, and 10-mg/kg doses, P < .05, χ2test.
↵4-k Significantly less than A10 control, 1- and 10-mg/kg doses, P < .05, χ2test.