Table 2

The effect of i.v. administration of SB-277011-A on the basal firing rate and pattern of spontaneously active A10 neurons

Parameter	Dose of SB-277011-A (μg/kg)
Parameter	0	10	20	40	80	160	320	640	1280
Spikes/burst^2-a	3.0 ± 0.5	2.9 ± 0.5	3.0 ± 0.5	3.0 ± 0.4	2.7 ± 0.6	2.6 ± 0.6	2.9 ± 0.4	3.1 ± 0.6	2.9 ± 0.5
Interspike interval (ms)^2-a	178 ± 11	175 ± 13	177 ± 10	179 ± 15	184 ± 12	194 ± 13	190 ± 13	186 ± 14	193 ± 17
Percentage of events as bursts^2-b	36	38	35	36	34	32	35	40	38
Coefficient of variation^2-a	69 ± 12	70 ± 13	67 ± 12	69 ± 13	65 ± 12	66 ± 13	66 ± 12	69 ± 13	67 ± 13

A total of nine neurons were examined at each dose. At the dose of 640 μg/kg, one of nine neurons being recorded was lost as were two of nine neurons at the 1280-μg/kg dose, i.e., an action potential for a DA neuron could no longer be detected. SB-277011-A was given i.v. in a cumulative fashion.

↵2-a Each value represents the mean ± S.E.
↵2-b Each value represents the mean.