Effects of SB-277011-A alone (A) and in combination with haloperidol (B) on catalepsy in rats
| A. Treatment (dose mg/kg) | Cataleptic Rats |
|---|---|
| Vehicle | 0 |
| Haloperidol (2.8) | 6 |
| SB-277011-A (2.5) | 1 |
| SB-277011-A (7.9) | 0 |
| SB-277011-A (25.2) | 0 |
| SB-277011-A (78.8) | 1 |
| B. Treatment (dose mg/kg) | Cataleptic Rats |
|---|---|
| Vehicle/saline | 1 |
| Vehicle/haloperidol (1.13) | 6 |
| SB-277011-A (2.5)/haloperidol (1.13) | 6 |
| SB-277011-A (7.9)/haloperidol (1.13) | 6 |
| SB-277011-A (25.2)/haloperidol (1.13) | 6 |
| SB-277011-A (78.8)/haloperidol (1.13) | 6 |
Data are for n = 6 per treatment group. A, rats were treated with SB-277011-A (p.o.) or haloperidol (2.8 mg/kg p.o.) and scored for catalepsy 180, 210, and 240 min later. B, rats were treated with SB-277011-A (p.o.) followed 150 min later by haloperidol (1.13 mg/kg p.o.). Rats were scored for catalepsy 180, 210, and 240 min after SB-271011-A administration. Data for the 240-min time points were analyzed by logistic regression analysis.