Vehicle | O-1623 | O-1624 | ||
---|---|---|---|---|
10 min after i.t. injection of vehicle or a dose of 200 μg | ||||
FAAH3-a | Spinal cord | 0.56 ± 0.08 | 0.04 ± 0.013-165 | 0.27 ± 0.043-165 |
Anandamide3-b | Spinal cord | 21.1 ± 2.9 | 27.2 ± 1.5 | 34.5 ± 2.23-150 |
2-Ara-Gl3-c | Spinal cord | 3.5 ± 0.5 | 2.9 ± 0.4 | 3.5 ± 0.6 |
5 min after i.v. injection of vehicle or a dose of 30 mg/kg | ||||
Anandamide3-b | Striatum | N.D.3-d | 30.4 ± 11.73-160 | |
2-Ara-Gl3-c | Striatum | 6.2 ± 1.0 | 11.3 ± 1.43-150 |
↵3-a Results are expressed in terms of nanomoles per minute per milligram of protein and presented as means ± S.E. for 8 to 10 animals per group.
↵3-b The values are picomoles per gram of tissue and presented as means ± S.E. for at least three animals per group.
↵3-c The results are expressed as nanomoles per gram of tissue and presented as means ± S.E. of at least three animals per group.
↵3-d N.D., not detected.
Significantly different from the vehicle group at
↵3-150 P < .05,
↵3-160 P= .06, and
↵3-165 P < .001.