Table 2

Agonist activity of BU48 and standard opioids on the electrically induced contractions of the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum and their antagonism by norBNI

IC50norBNI (Ke)
nM
BU481.38  ± 0.230.10  ± 0.05
DAMGO5.6  ± 1.813.0  ± 1.9
U6959331.4  ± 9.70.07  ± 0.01

Experiments were performed as described under Materials and Methods. Values represent means ± S.E. from three separate tissues and were determined as described under Materials and Methods.