Table 3

Correlations between β-elimination of selenocysteine Se-conjugates in human kidney cytosols

	Specific Activity		n	Intrinsic Clearance		n
	P^3-a	R²	n	P^3-a	R²	n
Alkyl-substituted (1–4)
Kidney I–kidney II	.0086	0.98	4
Kidney I–kidney III	.4701	0.29	4
Kidney II–kidney III	.3987	0.36	4
Phenyl-substituted (5–13)
Kidney I–kidney II	<.0001	0.96	9	.1005	0.80	5
Kidney I–kidney III	.0204	0.56	9	.1540	0.61	5
Kidney II–kidney III	.0037	0.72	9	.2341	0.42	5
Benzyl-substituted (14–22)
Kidney I–kidney II	<.0001	0.93	9	.0370	0.93	5
Kidney I–kidney III	.0058	0.69	9	.2002	0.64	5
Kidney II–kidney III	.0047	0.70	9	.0822	0.69	5
All compounds (1–22)
Kidney I–kidney II	<.0001	0.96	22	.0003	0.90	10
Kidney I–kidney III	<.0001	0.65	22	.0291	0.58	10
Kidney II–kidney III	<.0001	0.76	22	.0074	0.61	10