Influence of dosing time on pharmacokinetic parameters after IFN-β (0.5 MI.U./kg, intratumorally) injection at 9:00 AM or 9:00 PM
| Pharmacokinetic Parameters | Time of Drug Injection (Clock Hours) | Student's t Test | |
|---|---|---|---|
| 9:00 AM | 9:00 PM | ||
| CL (g protein/h/kg) | 1.156 ± 0.015 | 1.436 ± 0.019 | P < .01 |
| V c (g protein/kg) | 0.574 ± 0.006 | 0.587 ± 0.006 | N.S. |
| t 1/2α (× 10−1 h) | 0.587 ± 0.004 | 0.503 ± 0.004 | P < .01 |
| t 1/2β (× 10−1 h) | 7.677 ± 0.059 | 6.638 ± 0.054 | P < .01 |
| AUC (I.U. · h/mg protein) | 435.891 ± 5.298 | 350.641 ± 4.556 | P < .01 |
| MRT (h) | 0.894 ± 0.009 | 0.735 ± 0.008 | P < .01 |
Each value is the mean with S.E. of 44 to 51 mice.