Influence of treatment with PDE4 inhibitors for 6 days on RSV-induced IFN-γ levels in BALF
| Infection | Treatment | Dose | IFN-γ |
|---|---|---|---|
| mg/kg | pg/ml | ||
| Sham | 12.5 ± 9.4 | ||
| RSV | Vehicle | 1487.5 ± 185.71-150 | |
| RSV | Rolipram | 0.03 | 859.0 ± 38.4 |
| RSV | Rolipram | 0.1 | 1062.2 ± 294.2 |
| RSV | Rolipram | 0.3 | 992.8 ± 152.2 |
| Sham | 68.4 ± 13.1 | ||
| RSV | Vehicle | 980.9 ± 240.81-150 | |
| RSV | Ro-20-1724 | 1 | 1360.0 ± 79.7 |
| RSV | Ro-20-1724 | 3 | 1468.5 ± 481.1 |
Mice were innoculated with RSV (105 PFU) or PBS (sham). The mice were administered vehicle, rolipram, or Ro-20-1724 for 6 days, twice a day. On day 7, BALF was obtained and cytokine levels assayed.
↵1-150 P < .05 compared to sham-infected group. There were no differences between vehicle-treated groups and PDE4 inhibitor-treated groups (n = 6–12).