Antagonist | EC503-a | Emax3-b | Slope | pA2 |
---|---|---|---|---|
−log | % Inhibition | |||
None 5-CT (7) | 7.53 ± 0.1 | 72 ± 7.5 | 1.6 ± 0.4 | |
Ritanserin, 1.0 μM (4) | 6.61 ± 0.1 | 53 ± 2.7 | 1.5 ± 0.22 | 6.8 |
Methiothepin, 0.1 μM (8) | 7.35 ± 0.2 | 48 ± 4.4 | 2.3 ± 0.33 | |
Mesulergine, 0.1 μM (7) | 6.57 ± 0.2 | 54 ± 4.5 | 1.5 ± 0.20 | 7.9 |
SB-269770, 0.1 μM (3) | 5.68 ± 0.1 | 76 ± 6.3 | 1.1 ± 0.04 | 8.8 |
Values are mean ± S.E., and the number of cells is shown in parentheses.
↵3-a Significantly different ANOVA, F = 8.615, P < .001; 5-CT different from ritanserin, mesulergine and SB-269770, P< .05, by the Student-Newman-Keuls method.
↵3-b Significantly different ANOVA,F = 5.43, P = 0.003; 5-CT and SB-269770 different from methiothepin, P < .05, by the Student-Newman-Keuls method.