Dose | Bilirubin | GPT | LAP | ALP | γ-GTP | |
---|---|---|---|---|---|---|
mg/kg | mg/dl | I.U./l | mU/ml | |||
JBP 923 | ||||||
i.v. | 0 (normal rat) | 0.49 ± 0.06 | 39 ± 5 | 28 ± 7 | 109 ± 10 | 3.0 ± 0.3 |
0 (ANIT-treated rat) | 5.8 ± 0.4 | 330 ± 44 | 115 ± 3 | 314 ± 34 | 17.2 ± 1.8 | |
1.36 | 0.74 ± 0.031-160 | 130 ± 91-160 | 64 ± 231-150 | 136 ± 31-160 | 6.7 ± 0.61-160 | |
6.25 | 0.46 ± 0.061-160 | 99 ± 151-160 | 29 ± 91-160 | 120 ± 101-160 | 3.65 ± 0.061-160 | |
p.o. | 0 (normal rat) | 0.51 ± 0.07 | 35 ± 6 | 24 ± 6 | 130 ± 8 | 3.4 ± 0.4 |
0 (ANIT-treated rat) | 6.5 ± 0.5 | 385 ± 56 | 110 ± 16 | 363 ± 55 | 21.5 ± 2.1 | |
6.25 | 0.79 ± 0.141-160 | 233 ± 67 | 47 ± 71-160 | 196 ± 351-150 | 5.77 ± 0.081-160 | |
25 | 0.66 ± 0.091-160 | 68.3 ± 1.71-160 | 21.9 ± 2.01-160 | 113 ± 71-160 | 5.91 ± 0.271-160 | |
JBP 485 | ||||||
i.v. | 0 (normal rat) | 0.49 ± 0.06 | 39 ± 5 | 28 ± 7 | 109 ± 10 | 3.0 ± 0.3 |
0 (ANIT-treated rat) | 5.8 ± 0.4 | 330 ± 44 | 115 ± 3 | 314 ± 34 | 17.2 ± 1.8 | |
1.36 | 1.11 ± 0.061-160 | 238 ± 161-150 | 54 ± 31-160 | 253 ± 331-150 | 7.9 ± 0.51-160 | |
6.25 | 0.46 ± 0.071-160 | 153 ± 31-160 | 25.5 ± 2.01-160 | 133 ± 101-160 | 3.65 ± 0.061-160 | |
p.o. | 0 (normal rat) | 0.51 ± 0.07 | 35 ± 6 | 24 ± 6 | 130 ± 8 | 3.4 ± 0.4 |
0 (ANIT-treated rat) | 6.5 ± 0.5 | 385 ± 56 | 110 ± 16 | 363 ± 55 | 21.5 ± 2.1 | |
6.25 | 1.2 ± 0.31-160 | 119 ± 511-160 | 49 ± 51-160 | 194 ± 111-150 | 9.8 ± 0.81-160 | |
25 | 0.68 ± 0.211-160 | 62 ± 131-160 | 28 ± 51-160 | 104 ± 241-160 | 4.52 ± 0.111-160 |