Compound (mol. wt.) | Papp (× 10−6 cm/s) | |
---|---|---|
ME3229 (560.7) | Total RI2-a | 7.9 ± 0.3 |
ME32292-b | 1.1 ± 0.1 | |
PM-102-b | 3.4 ± 0.4 | |
PM-112-b | 0.079 ± 0.040 | |
ME32772-b | 0.68 ± 0.12 | |
ME3277 (446.5) | Total RI2-a | 0.085 ± 0.003 |
Mannitol (182.2) | Total RI2-a | 0.36 ± 0.09 |
↵2-a The radiolabeled compound was added to the mucosal medium, and the flux of radioactivity appearing in the serosal medium was used as dA/dt in eq. 1.
↵2-b Unlabeled ME3229 was added to the mucosal medium, and the flux of each metabolite appearing in the serosal medium was used as dA/dt in eq. 1.