Hemodynamics
| n | Baseline | 15-min Ischemia | 2-h Reperfusion | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Heart Rate | MBP | RPP | Heart Rate | MBP | RPP | Heart Rate | MBP | RPP | ||
| Control | 9 | 342 ± 14 | 81 ± 4 | 37 ± 1 | 360 ± 14 | 79 ± 5 | 35 ± 2 | 373 ± 20 | 64 ± 10 | 33 ± 5 |
| TAN-67 | 7 | 346 ± 11 | 73 ± 5 | 33 ± 2 | 336 ± 11 | 70 ± 5 | 29 ± 2 | 376 ± 18 | 54 ± 4 | 28 ± 2 |
| 5-HD | 5 | 358 ± 21 | 96 ± 10 | 46 ± 5 | 362 ± 21 | 82 ± 10 | 35 ± 5 | 312 ± 13 | 71 ± 8 | 28 ± 4 |
| 5-HD + TAN-67 | 8 | 344 ± 22 | 87 ± 3 | 43 ± 6 | 346 ± 22 | 78 ± 11 | 34 ± 5 | 345 ± 28 | 78 ± 5 | 35 ± 1 |
| HMR 1098 | 6 | 327 ± 10 | 115 ± 12 | 48 ± 4 | 296 ± 12 | 98 ± 9 | 35 ± 2 | 354 ± 11 | 67 ± 7 | 33 ± 4 |
| HMR 1098 + TAN-67 | 5 | 327 ± 24 | 104 ± 8 | 39 ± 5 | 290 ± 28 | 99 ± 7 | 32 ± 3 | 288 ± 27 | 93 ± 61-150 1-160 | 33 ± 4 |
Values given as mean ± S.E. Heart rate (beats/min), MBP (mm Hg); rate-pressure product (RPP, mm Hg · min−1 · 1000−1); 5-HD, 5 min before either control or TAN-67 treatment protocol; HMR 1098, 3 mg/kg, 5 min before either control or TAN-67 treatment protocol.