Table 1

Mouse Formalin test

Early Phase (0–10 min)Late Phase (10–45 min)
CI-1021 (mg/kg, s.c.)
 0129.0  ± 6.2206.0  ± 8.2
 1111.8  ± 6.1162.7  ± 15.1
 3144.0  ± 18.0105.3  ± 20.21-150
 1094.0  ± 12.288.3  ± 15.61-160
 30105.9  ± 11.383.3  ± 16.41-160
CP 99,994 (mg/kg, s.c.)
 0149.3  ± 14.0264.5  ± 22.0
 3152.8  ± 12.0186.3  ± 33.7
 10139.6  ± 12.0159.7  ± 25.01-150
 3099.8  ± 12.01-150 153.3  ± 25.01-150
SR 140333 (mg/kg, s.c.)
 0125.8  ± 13.0252.2  ± 19.0
 1134.2  ± 13.0253.0  ± 26.0
 3123.2  ± 11.0162.4  ± 23.01-150
 10125.3  ± 14.0144.6  ± 32.01-160
 30110.0  ± 9.0118.6  ± 24.01-160
 100116.0  ± 17.069.6  ± 14.01-160
PD 156982 (mg/kg, s.c.)
 0122.0  ± 10.0149.4  ± 20.0
 1141.0  ± 14.0178.0  ± 31.0
 3122.0  ± 14.0176.9  ± 25.0
 10114.0  ± 5.0151.0  ± 28.0
 30147.3  ± 17.0171.0  ± 30.0
PD 156982 (μg/animal, i.c.v.)
 063.0  ± 9.7203.4  ± 20.4
 3045.5  ± 8.058.0  ± 20.01-160

The data are shown as mean ± S.E. (n = 7–10) time (s) spent licking/biting the injected paw (20 μl of 5% formalin)

  • ↵1-150  P < .05,

  • ↵1-160  P < .01 significantly different from vehicle-treated (0). (ANOVA followed by Dunnett's t test; unpaired t test for i.c.v. data).