Contractility parameters as a function of genotype distributions for kinin receptor gene polymorphisms
| Genotypes (n) | Sar-[d-Phe8]des-Arg9-BK, 2 h Emax1-a | Sar-[d-Phe8]des-Arg9-BK, 6 h | BK, 4 h | |||
|---|---|---|---|---|---|---|
| Emax | EC501-b | Emax | EC50 | |||
| Pool | (100) | 34.4; 37.1 ± 2.1 | 71.8; 68.9 ± 2.9 | 289; 695 ± 124 | 106.3; 106.1 ± 2.3 | 16.3; 88.4 ± 27.0 |
| B1R, exon 3 | AA (88) | 34.4; 36.7 ± 2.3 | 71.8; 70.1 ± 3.0 | 297; 655 ± 115 | 105.7; 105.7 ± 2.7 | 17.4; 93.7 ± 30.5 |
| AG (12) | 40.9; 40.2 ± 6.4 | 70.5; 59.8 ± 8.5 | 166; 995 ± 616 | 104.1; 100.5 ± 6.6 | 6.5; 50.4 ± 25.6 | |
| GG (0) | ||||||
| B1R, promoter | GG (86) | 35.2; 37.5 ± 2.1 | 72.3; 68.8 ± 3.2 | 263; 701 ± 139 | 106.4; 106.9 ± 3.0 | 16.3; 87.9 ± 30.6 |
| CG (14) | 26.5; 34.3 ± 8.0 | 64.0; 65.1 ± 7.4 | 452; 656 ± 237 | 104.8; 110.7 ± 5.3 | 17.0; 91.4 ± 44.2 | |
| CC (0) | ||||||
| B2R, exon 2 | CC (81) | 35.0; 37.1 ± 2.3 | 69.5; 70.4 ± 3.1 | 268; 547 ± 84 | 105.5; 105.4 ± 2.4 | 12.1; 87.4 ± 32.6 |
| CT (19) | 28.3; 37.1 ± 5.3 | 75.8; 62.5 ± 7.2 | 451; 1328 ± 532 | 109.6; 109.4 ± 6.2 | 38.8; 92.5 ± 30.51-c | |
| TT (0) | ||||||
| B2R, promoter | CC (34) | 34.3; 37.7 ± 3.5 | 75.2; 74.6 ± 5.0 | 261; 505 ± 132 | 109.2; 107.5 ± 4.1 | 15.6; 157.9 ± 75.1 |
| CT (50) | 35.1; 37.4 ± 3.0 | 68.4; 67.3 ± 3.6 | 228; 856 ± 225 | 106.0; 107.5 ± 3.0 | 18.9; 46.3 ± 11.5 | |
| TT (16) | 29.1; 34.8 ± 5.9 | 73.4; 61.8 ± 8.7 | 394; 596 ± 156 | 102.1; 99.3 ± 6.4 | 7.5; 76.5 ± 46.6 | |
| B2R, exon 1 | +/+ (25) | 36.5; 36.9 ± 3.7 | 71.8; 70.8 ± 5.6 | 237; 651 ± 305 | 105.4; 108.1 ± 4.2 | 15.6; 42.4 ± 17.4 |
| +/− (50) | 32.1; 37.3 ± 3.2 | 67.2; 62.3 ± 3.6 | 310; 880 ± 186 | 107.9; 103.5 ± 3.4 | 17.5; 90.8 ± 23.5 | |
| −/− (25) | 35.0; 36.7 ± 4.4 | 78.2; 80.0 ± 6.51-d | 151; 368 ± 1091-e | 105.4; 109.7 ± 4.3 | 14.2; 135.1 ± 99.0 | |
Alleles and genotypes were designated either by the (+) and (−) symbols for the B2R gene insertion/deletion polymorphism, or by the initial of the polymorphic base for the four other polymorphisms.
↵1-a Emax values (median; mean ± S.E.) expressed as a percentage of the maximal response to 5-HT (10 μM) established for each tissue at time 7 h.
↵1-b EC50 values (median; mean ± S.E.) are nanomolar concentrations.
↵1-c P = .023, compared to the CC genotype (Mann-Whitney).
↵1-d P = .044, compared to the +/− genotype, P = .064 (nonsignificant), compared to the pooled values of the +/+ and +/− genotypes and P = .30 (nonsignificant), compared to the +/+ genotype (Mann-Whitney).
↵1-e P = .027, compared to the +/− genotype, P = .07 (nonsignificant), compared with pooled values of the +/+ and +/− genotypes and P = .62 (nonsignificant), compared to the +/+ genotype (Mann-Whitney).