Table 2

Parameter estimates (with CI₉₅) obtained and calculated according to Fig. 3 from the effect of antagonists on stimulation-evoked tritium overflow

	E_max	pEC₅₀	pEC_50-corr	pK_b
Rauwolscine	67 (52, 87) %	8.01 (7.07, 8.69)	7.84	8.70
Idazoxan	73 (62, 84) %	7.09 (6.80, 7.43)	6.92	7.78
WB4101	48 (42, 56) %	7.15 (6.84, 7.52)	6.98	7.84
Phentolamine	67 (57, 78) %	6.76 (6.47, 7.05)	6.59	7.45
Spiroxatrine	69 (60, 82) %	6.20 (5.88, 6.50)	6.03	6.89
Corynanthine	71 (53, 105) %	5.42 (5.07, 5.73)	5.25	6.11
Prazosin	64 (42, 120) %	5.46 (4.90, 5.90)	5.29	6.15
SKF104078	47 (35, 68) %	5.71 (5.25, 6.15)	5.54	6.40
ARC239	36 (24, 54) %	5.45 (4.91, 5.95)	5.28	6.14

The estimates were obtained from the experiments of Fig. 2.E_max, maximum enhancement by the antagonist; pEC₅₀, negative logarithm of EC₅₀, derived from logistic curve fitting. The slope factor c was assumed to be 1. pEC_50-corr corresponds to the 1.49-fold increase in EC₅₀ as explained in the Discussion, and pK_b = pEC_50-corr + 0.87, according to Fig.3.