Autoinhibition-Free Conditions | Autoinhibition Conditions |
---|---|
I max observed 79.0 (70.5, 89.5) % | I max derived 82.6 (70.9, 87.7) % |
pIC50 8.07 (7.84, 8.29) | pK d 7.99 (7.50, 8.31) |
c 0.98 (0.65, 1.75) | p[NEtr] 7.61 (7.45, 7.77) |
The estimates were obtained from the experiments of Fig. 1. Autoinhibition-free conditions: Imax observed, maximum inhibition by exogenous noradrenaline; pIC50, negative logarithm of IC50; c, slope parameter. Autoinhibition conditions: Imax derived, maximum obtainable effect of noradrenaline under autoinhibition-free conditions; pKd, negative logarithm of the dissociation constant of the noradrenaline-autoreceptor complex; p[NEtr], negative logarithm of the concentration of released transmitter noradrenaline at the autoreceptors in the absence of exogenous noradrenaline (duringS1).