Estimated steady-state plasma concentrations (±S.E.M.) of dexmedetomidine or midazolam in the studies I to IV, that correspond to a 50% probability of no response to a particular stimulus
| WR | RR | SR | TC | CR | |
|---|---|---|---|---|---|
| Dexmedetomidine (ng/ml) | |||||
| Study I (no midazolam) | 1.09 ± 0.10 | 2.13 ± 0.15 | 3.75 ± 0.64 | 5.49 ± 1.34 | 24.5 ± 12.3 |
| Study II (0.097 ± 0.001 μg/ml midazolam) | 0.51 ± 0.03 | 0.72 ± 0.05 | 0.86 ± 0.10 | 1.34 ± 0.15 | 2.63 ± 0.40 |
| Study III (0.37 ± 0.01 μg/ml midazolam) | 0.19 ± 0.02 | 0.26 ± 0.03 | 0.25 ± 0.06 | 0.77 ± 0.07 | 1.86 ± 0.12 |
| Midazolam (μg/ml) | |||||
| Study IV | 0.51 ± 0.191-a | 7.23 ± 1.12 | 15.3 ± 2.7 | 22.6 ± 2.0 | 60.7 ± 21.9 |
↵1-a Including midazolam baseline data from studies II and III.