Organ | nmol/g | % of Dose |
---|---|---|
Liver | 8.1 ± 1.20 | 0.090 |
i.p. fat | 50 ± 5.10 | 0.110 |
Lung | 7.4 ± 1.60 | 0.010 |
Heart | 3.3 ± 0.30 | 0.003 |
Stomach | 16.2 ± 2.50 | 0.040 |
Intestine | 10.5 ± 0.70 | 0.020 |
Mammary Gland | 40.0 ± 7.70 | 0.100 |
Uterus | 12.0 ± 3.10 | 0.010 |
Brain | 2.6 ± 0.60 | 0.002 |
Kidney | 12.8 ± 3.00 | 0.030 |
All values represent means ± S.E. of tissues from three individual animals. The concentration of total 3H, representing residual MC and its metabolites, in each organ was measured 15 days after cessation of MC treatment. Radioactivity in carcasses was measured after all the major organs had been dissected. The total radioactivity in the carcasses (35 g) was 132,440 ± 13,000 dpm, which corresponded to 70 nmol of MC and its metabolites.