Table 3

Correlation between trough blood and tissue concentrations of SDZ-RAD, cyclosporine, and their metabolites

Tissue	SDZ-RAD		SDZ-RAD Metabolites		Cyclosporine		Cyclosporine Metabolites
Tissue	r^4-a	<P	r	<P	r	<P	r	<P
Brainstem	0.57	.01	0.32	—^4-b	0.65	.004	0.75	.001
Cerebellum	−0.10	—	−0.15	—	0.48	.04	−0.01	—
Cerebrum	0.46	.05	0.01	—	0.55	.007	0.21	—
Colon	0.17	—	0.07	—	0.36	—	0.23	—
Duodenum	0.18	—	0.57	.01	0.79	.001	0.86	.001
Fat	0.70	.002	0.36	—	0.33	—	0.54	.03
Gall bladder	0.47	.045	0.19	—	0.66	.001	0.39	—
Heart	0.56	.01	0.43	—	0.85	.001	0.29	—
Ileum	0.48	.04	0.65	.002	0.69	.001	0.73	.001
Jejunum	0.36	—	0.38	—	0.81	.001	0.85	.001
Kidney	0.42	—	−0.02	—	0.63	.004	0.84	.001
Liver	0.68	.002	0.08	—	0.75	.001	0.81	.001
Lung (native)	0.16	—	0.32	—	0.83	.001	0.33	—
Lung (tx)	0.51	.04	0.24	—	0.73	.001	0.84	.001
Lymph node	0.33	—	0.04	—	0.68	.001	0.43	—
Pancreas	−0.36	—	−0.2	—	0.63	.004	0.43	—
Spleen	0.76	.001	0.08	—	0.80	.001	0.53	.01
Stomach	0.34	—	0.40	—	0.65	.001	0.37	—
Testes	0.61	.002	−0.80	—	0.77	.001	0.48	.02
Thymus	0.39	—	0.01	—	0.64	.006	0.48	.04

The data of all study groups (n = 25) were entered in the analysis.