Table 1

Effects of nerve toxins on relaxation to EFS in canine LES

EFS at 5 pps, 40 V for 10 s
0.1 ms0.2 ms0.3 ms
g
Controls (no toxins)1.50  ± 0.121.86  ± 0.112.28  ± 0.39
ω-CTX(GVIA) (10−7 M)0.36  ± 0.071-150 0.70  ± 0.101-150 0.86  ± 0.12
(24%)1-a (38%)1-a (38%)1-a
TTX (10−6 M) [plus ω-CTX(GVIA)]1-b 01-150 01-150 01-150

  • ↵1-a Values in parentheses represent percentage of control relaxation after ω-CTX(GVIA).

  • ↵1-b TTX also abolished relaxations when administered alone.

  • ↵1-150  P ≤ .01, differ from control due to chance (n = 11).