Relationships between cocaine intake and postsession PRL and CORT on days 1 and 5 of SA testing in rats that had acquired cocaine SA ( ACQ ) and rats that failed to meet the acquisition criterion ( NON-ACQ )
| Self-Administration Test Day | Subjects | Cocaine Intake | Postsession CORT | CORT and Intake r Value | Postsession PRL | PRL and Intaker Value |
|---|---|---|---|---|---|---|
| mg/kg | ng/ml | ng/ml | ||||
| Day 1 | ACQ (n = 26) | 54.252-a ± 5.30 | 201.492-a ± 28.22 | +0.4342-b | 1.192-a ± 0.34 | −0.4842-b |
| NON-ACQ (n = 20) | 13.40 ± 2.38 | 80.58 ± 19.39 | +0.4932-b | 3.23 ± 0.78 | −0.471 | |
| Day 5 | ACQ (n = 37) | 74.422-a ± 5.56 | 238.722-a ± 22.26 | +0.034 | 2.31 ± 0.47 | +0.226 |
| NON-ACQ (n = 9) | 19.08 ± 6.25 | 126.40 ± 42.10 | +0.8582-b | 2.80 ± 0.79 | −0.7582-b |
Correlation coefficients (r values) were determined using linear regression analysis. The statistical significances of differences in cocaine intake, CORT, and PRL between ACQ and NON-ACQ rats on each test day were determined using unpaired Student'st tests. The criterion for acquisition was set as an intake of at least 4.0 mg/kg cocaine within four of five consecutive 2-h time bins, and the point of acquisition was defined as the first of the time bins within which this criterion was met. Values are mean ± S.E.