Table 1

Daily relationships (r values) between cocaine intake (mg/kg over the entire 10-h session) and postsession plasma PRL and CORT determined on each of the 5 consecutive days of testing for groups of rats provided access to one of the four doses of cocaine for SA

	Baseline	SA Test Day
		Day 1		Day 2		Day 3		Day 4		Day 5
		Day 1		Day 2		Day 3		Day 4		Day 5
	PRL CORT	Cocaine Intake	PRL CORT	rValue	Cocaine Intake	PRL CORT	rValue	Cocaine Intake	PRL CORT	rValue	Cocaine Intake	PRL CORT	rValue	Cocaine Intake	PRL CORT	r Value
Cocaine (mg/kg/infusion)	ng/ml	mg/kg	ng/ml		mg/kg	ng/ml		mg/kg	ng/ml		mg/kg	ng/ml		mg/kg	ng/ml
0.25	6.06 ± 1.84	15.96 ± 3.65	3.05 ± 0.66	−0.315	18.09 ± 4.33	1.86 ± 0.56	−0.019	16.96 ± 3.79	3.35 ± 1.10	0.063	25.07 ± 4.75	1.64 ± 0.84	−0.127	26.75 ± 5.78	2.38 ± 0.78	−0.175
	73.35 ± 14.60		141.35 ± 46.83	0.786^1-a		97.88 ± 26.15	0.693^1-a		114.29 ± 22.61	0.401		155.86 ± 36.62	0.562		232.28 ± 48.18	0.624^1-a
0.5	6.48 ± 1.60	26.32 ± 5.68	2.17 ± 0.75	−0.031	25.07 ± 4.75	2.50 ± 0.74	−0.254	26.96 ± 5.72	1.46 ± 0.92	−0.600	34.18 ± 5.26	0.90 ± 0.33	−0.218	48.50 ± 6.02	1.28 ± 0.54	−0.516
	64.26 ± 19.55		113.25 ± 34.52	0.435		165.18 ± 36.78	0.762^1-a		160.72 ± 38.14	0.740^1-a		172.48 ± 42.86	0.366		212.37 ± 40.24	0.787^1-a
1.0	6.20 ± 1.42	41.83 ± 7.65	2.05 ± 1.15	−0.713^1-b	47.33 ± 7.67	1.43 ± 0.46	−0.650^1-b	61.58 ± 9.63	1.85 ± 0.43	−0.632	68.58 ± 10.91	1.04 ± 0.52	−0.314	74.92 ± 9.24	2.89 ± 0.99	−0.033
	39.96 ± 17.46		191.57 ± 43.72	0.809^1-a		126.45 ± 20.50	0.827^1-a		212.30 ± 25.81	0.424		228.09 ± 36.74	0.455		210.95 ± 43.92	0.613
2.0	7.49 ± 2.4	62.55 ± 10.76	0.88 ± 0.42	−0.532	70.36 ± 7.72	2.17 ± 0.77	0.087	85.82 ± 7.65	3.77 ± 0.79	0.206	95.46 ± 8.53	2.76 ± 1.42	0.507	102.18 ± 9.28	3.25 ± 0.98	0.348
	34.51 ± 10.32		157.99 ± 37.68	0.845^1-a		184.16 ± 24.30	0.339		238.47 ± 31.38	0.453		204.20 ± 30.82	0.586		209.81 ± 35.96	0.806^1-a

The r values were determined using linear regression analysis. Intakes represent the total cocaine intake during the 10-h SA session, immediately after which blood samples were obtained for hormonal determinations. Values are mean ± S.E.

↵1-a Significant positive correlation (P < .05).
↵1-b Significant negative correlation (P < .05).