Baseline | SA Test Day | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | ||||||||||||
PRL CORT | Cocaine Intake | PRL CORT | rValue | Cocaine Intake | PRL CORT | rValue | Cocaine Intake | PRL CORT | rValue | Cocaine Intake | PRL CORT | rValue | Cocaine Intake | PRL CORT | r Value | |
Cocaine (mg/kg/infusion) | ng/ml | mg/kg | ng/ml | mg/kg | ng/ml | mg/kg | ng/ml | mg/kg | ng/ml | mg/kg | ng/ml | |||||
0.25 | 6.06 ± 1.84 | 15.96 ± 3.65 | 3.05 ± 0.66 | −0.315 | 18.09 ± 4.33 | 1.86 ± 0.56 | −0.019 | 16.96 ± 3.79 | 3.35 ± 1.10 | 0.063 | 25.07 ± 4.75 | 1.64 ± 0.84 | −0.127 | 26.75 ± 5.78 | 2.38 ± 0.78 | −0.175 |
73.35 ± 14.60 | 141.35 ± 46.83 | 0.7861-a | 97.88 ± 26.15 | 0.6931-a | 114.29 ± 22.61 | 0.401 | 155.86 ± 36.62 | 0.562 | 232.28 ± 48.18 | 0.6241-a | ||||||
0.5 | 6.48 ± 1.60 | 26.32 ± 5.68 | 2.17 ± 0.75 | −0.031 | 25.07 ± 4.75 | 2.50 ± 0.74 | −0.254 | 26.96 ± 5.72 | 1.46 ± 0.92 | −0.600 | 34.18 ± 5.26 | 0.90 ± 0.33 | −0.218 | 48.50 ± 6.02 | 1.28 ± 0.54 | −0.516 |
64.26 ± 19.55 | 113.25 ± 34.52 | 0.435 | 165.18 ± 36.78 | 0.7621-a | 160.72 ± 38.14 | 0.7401-a | 172.48 ± 42.86 | 0.366 | 212.37 ± 40.24 | 0.7871-a | ||||||
1.0 | 6.20 ± 1.42 | 41.83 ± 7.65 | 2.05 ± 1.15 | −0.7131-b | 47.33 ± 7.67 | 1.43 ± 0.46 | −0.6501-b | 61.58 ± 9.63 | 1.85 ± 0.43 | −0.632 | 68.58 ± 10.91 | 1.04 ± 0.52 | −0.314 | 74.92 ± 9.24 | 2.89 ± 0.99 | −0.033 |
39.96 ± 17.46 | 191.57 ± 43.72 | 0.8091-a | 126.45 ± 20.50 | 0.8271-a | 212.30 ± 25.81 | 0.424 | 228.09 ± 36.74 | 0.455 | 210.95 ± 43.92 | 0.613 | ||||||
2.0 | 7.49 ± 2.4 | 62.55 ± 10.76 | 0.88 ± 0.42 | −0.532 | 70.36 ± 7.72 | 2.17 ± 0.77 | 0.087 | 85.82 ± 7.65 | 3.77 ± 0.79 | 0.206 | 95.46 ± 8.53 | 2.76 ± 1.42 | 0.507 | 102.18 ± 9.28 | 3.25 ± 0.98 | 0.348 |
34.51 ± 10.32 | 157.99 ± 37.68 | 0.8451-a | 184.16 ± 24.30 | 0.339 | 238.47 ± 31.38 | 0.453 | 204.20 ± 30.82 | 0.586 | 209.81 ± 35.96 | 0.8061-a |
The r values were determined using linear regression analysis. Intakes represent the total cocaine intake during the 10-h SA session, immediately after which blood samples were obtained for hormonal determinations. Values are mean ± S.E.