Fractional release of radioactivity on electrical stimulation of tissues pretreated for 20 min with DMSO (0.01%, v/v) or the indicated AT1 angiotensin II receptor blocker (10−6 M)
| Treatment | FR1 | n |
|---|---|---|
| DMSO | 0.54 ± 0.05 | 10 |
| Losartan | 0.64 ± 0.06 | 11 |
| Eprosartan | 0.61 ± 0.05 | 11 |
| Irbesartan | 0.54 ± 0.03 | 11 |
| Valsartan | 0.53 ± 0.05 | 11 |
FR1 is the fractional release of radioactivity evoked by the electrical stimulus and is calculated by subtracting the resting radioactivity from the total radioactivity content of the 5-min sample collected during the stimulation period and expressed as a percentage of the total tissue radioactivity at that time. The exposure of the tissues to the vehicle (DMSO) or the indicated agent commenced 20 min before S1 and continued for the rest of the experiment. Results are expressed as mean ± S.E. The differences in the values obtained with tissues treated with DMSO and losartan, eprosartan, irbesartan, or valsartan were not statistically significant (Dunnett's test).