Treatment | IC50 | ||
---|---|---|---|
SNC 80 | Morphine | U50488H | |
M | |||
Control | 6.97 × 10−10 ± 2.22 | 5.60 × 10−9 ± 1.35 | 1.33 × 10−6 ± 0.21 |
Sham | 4.33 × 10−10 ± 1.61 | 5.48 × 10−9 ± 0.53 | |
BDL (day 2) | 2.12 × 10−8 ± 0.322-a | ||
(day 5) | 1.70 × 10−7 ± 0.202-a 2-b | 8.50 × 10−7 ± 0.952-a | 1.84 × 10−6 ± 0.32 |
(day 10) | 5.65 × 10−7 ± 0.752-a 2-b 2-c | ||
(day 15) | 8.02 × 10−7 ± 1.252-a 2-b 2-c | ||
BDL (day 5) + β-FNA | 2.22 × 10−7 ± 0.102-a 2-b | ||
BDL (day 5) + nor-BNI | 3.51 × 10−6 ± 0.142-a 2-d | ||
Degree of subsensitivity (day 5) | 244 | 152 | 1 |
Each value represents mean inhibitory concentration that inhibits electrically induced twitches ± S.E. (n = 6).