Table 2

Enzyme kinetic parameter sets used to generate metabolite formation rates

Type of Inhibition	Parameter		Substrate	Inhibitor	Reference
Type of Inhibition	V_max	K_m	Substrate	Inhibitor	Reference	K_i
	nmol · min⁻¹ · mg protein⁻¹	μM
Competitive	0.34	20	0.4	Dextromethorphan	Quinidine	Bourrie et al., 1996
	2.6	11.9	12.1	Midazolam	Morpholine-urea-Phe-HPhe-vinylsulfone	Zhang et al., 1998
	0.14	0.34	4	Coumarin	Pilocarpine	Bourrie et al., 1996
Noncompetitive	13.7	30	0.6	Phenacetin	Furafylline	Bourrie et al., 1996
	0.6	67.5	84.4	Dextromethorphan	Omeprazole	Ko et al., 1998
	0.1^2-a	0.35	36	Benzyloxyresorufin	Clonezepam	Nims et al., 1997