Effects of isoproterenol, CL316,243, procaterol, atropine, verapamil, and papaverine on heart rate in urethane-anesthetized rats
| Drug | Dose (i.v.) | ||||||
|---|---|---|---|---|---|---|---|
| 0 | 0.1 | 1 | 10 | 100 | 1,000 | 10,000 | |
| μg/kg | |||||||
| Isoproterenol | 100.3 ± 0.2 | 107.6 ± 3.2 | 122.6 ± 1.83-a | 121.4 ± 4.13-a | |||
| CL316,243 | 100.1 ± 0.2 | 101.8 ± 0.4 | 101.2 ± 0.43-a | 100.6 ± 0.4 | 100.1 ± 0.8 | ||
| Procaterol | 100.9 ± 0.5 | 103.2 ± 1.3 | 103.8 ± 1.5 | 106.2 ± 1.9 | 106.0 ± 2.3 | ||
| Atropine | 99.9 ± 0.1 | 102.0 ± 0.3 | 103.8 ± 1.8 | 102.0 ± 1.8 | |||
| Verapamil | 100.3 ± 0.3 | 100.1 ± 0.3 | 95.1 ± 2.23-a | 78.9 ± 4.53-a | |||
| Papaverine | 100.0 ± 0.3 | 100.4 ± 0.2 | 101.4 ± 0.4 | 79.5 ± 2.73-a | |||
Results are expressed as a percentage of the value before drug administration, and are given as the mean ± S.E. of data from seven to eight animals. The values show the maximum response during the observation for 30 min after the drug administration.
↵3-a Indicates significant difference from saline control (0 μg/kg) (P < .05).