Table 2

Comparative maximal antiarrhythmic effects of moxonidine (MOX, 25 μg/kg i.v.) and propranolol (PRO, 500 μg/kg i.v.) in six halothane-anesthetized rabbits

% Relative Effect	NbES	NbAC	d	D
MOX versus before injection	−83^**	−33^*	+65^**	−35^*
	(15 min)	(75 min)	(55 min)	(15 min)
MOX versus saline	−81^*	−35	+81^***	−31^*
	(15 min)	(15 min)	(55 min)	(55 min)
PRO versus before injection	−98^**	−79^**	+188	−58^**
	(35 min)	(35 min)	(55 min)	(35 min)
PRO versus saline	−96^**	−81^*	+155	−55^*
	(35 min)	(15 min)	(55 min)	(35 min)
PRO versus MOX	−92^*	−74^*	+72	−39
	(140 min)	(55 min)	(35 min)	(35 min)

Data are expressed in percentage of variation (%). Numbers in parentheses indicate the kinetic of maximal antiarrhythmic effects (time after i.v. injection of drug).

d, delay of arrhythmias onset after the start of stimulation; D, total duration of arrhythmias for each stimulation.
*P < .05; ** P < .01; ***P < .001 (Contrast method comparison).