Table 1

Effect of mouse strain, age, and excess unlabeled AIT-082 on influx of [¹⁴C]AIT-082

Mouse Strain	Influx Constant (K_i)
Mouse Strain	Swiss-Webster	C57BL/6	Aged C57BL/6^1-a
		μl g⁻¹min⁻¹
Control	0.60 ± 0.20^1-b (n = 7)	0.35 ± 0.06 (n = 7)	0.33 ± 0.02 (n = 3)
Excess AIT-082
110-fold	0.40 ± 0.11 (n = 4)	0.25 ± 0.08 (n = 7)	ND
650-fold	0.40 ± 0.02 (n = 4)	0.24 ± 0.08 (n = 5)	ND

ND, not determined.
↵1-a Aged animals were 13 to 25 months of age.
↵1-b Data shown are mean ± S.E.