Table 1

Activating potencies of tectoridin and 3′-TTR relative to that of ryanodine for RyR1

CompoundAffinity IC50Activation Potency EC50actCalculated Fold Loss in Affinity1-aExpected EC50actBased on Fold Loss in Affinity1-bFold Increase in EC50act1-c
nM μM μM
Ryanodine6.22.31.02.31.0
TTR17300750279064178.6
3′-TTR6600480106424475.1
  • 1-a Affinity of compound/affinity of ryanodine.

  • 1-b Affinity of compound × EC50actof ryanodine.

  • 1-c Expected EC50act of compound/experimental EC50act of compound.