Kact and Vmax values for DMT and gramine at native and D155E 5-HT2A receptors
| Native | D155E | |
|---|---|---|
| Gramine | ||
| K act | >100,000 | 28,600 ± 6,6002-150 |
| V max | <100 | 1,158 ± 992-150 |
| DMT | ||
| K act | 1,620 ± 54 | 19,590 ± 6412-150 |
| V max | 1,589 ± 88 | 1,354 ± 146 |
Data represent mean ± S.E. (n = 3) for computer-derived estimates of Kact andVmax values for DMT and gramine at 5-HT2Aand D155E receptors.
↵2-150 P < .01 versus native receptor.