Table 1

Effect of exposure to 3 ppm O3 for 1 h on reactivity to extraluminal and intraluminal MCh in the perfused trachea

Treatment (n)EC50 (95% CI)Maximum ResponseIL/EL Maximum Response Ratio
ELILELIL
M cm H2O
0 h
 Air (8)2.6  × 10−7 2.0  × 10−4 1-a 28.9  ± 4.016.8  ± 3.41-b 0.58  ± 0.06
(1.8–3.8)(0.4–8.9)
 O3 (8)1.7  × 10−7 3.7  × 10−5 1-a 1-c 16.9  ± 4.813.6  ± 4.21-b 0.72  ± 0.051-d
(0.9–3.4)(1.8–7.7)
2 h
 Air (5)2.5  × 10−7 2.7  × 10−4 1-a 13.0  ± 3.38.5  ± 1.61-b 0.71  ± 0.07
(1.5–4.2)(0.9–8.3)
 O3 (5)3.2  × 10−7 1.3  × 10−4 1-a 13.3  ± 2.29.5  ± 1.61-b 0.71  ± 0.01
(2.0–5.3)(0.6–2.9)
6 h
 Air (5)2.0  × 10−7 4.3  × 10−4 1-a 13.2  ± 2.28.9  ± 1.51-b 0.66  ± 0.03
(1.2–3.3)(1.6–11.4)
 O3 (5)2.5  × 10−7 1.5  × 10−4 1-a 14.5  ± 2.28.6  ± 1.71-b 0.58  ± 0.04
(1.7–3.6)(0.7–3.2)
12 h
 Air (6)2.6  × 10−7 3.2  × 10−4 1-a 9.3  ± 1.66.0  ± 1.01-b 0.67  ± 0.04
(1.6–4.0)(2.0–5.4)
 O3 (6)2.9  × 10−7 3.8  × 10−4 1-a 16.2  ± 2.78.9  ± 1.61-b 0.54  ± 0.211-e 1-f
(2.3–3.8)(2.5–5.7)
18 h
 Air (7)2.7  × 10−7 8.0  × 10−4 1-a 14.0  ± 1.68.4  ± 0.91-b 0.60  ± 0.03
(2.2–3.4)(4.7–13.7)
 O3 (7)2.2  × 10−7 7.4  × 10−4 1-a 10.8  ± 1.75.8  ± 0.81-b 0.55  ± 0.041-e
(1.8–2.8)(2.1–2.6)

  • ↵1-a Significantly larger than EL.

  • ↵1-b Significantly less than EL. There were no differences in the IL/EL ratios between the air-treated controls.

  • ↵1-c Significantly smaller than air.

  • ↵1-d Significantly larger than air.

  • ↵1-e Significantly less than 0 and 2 h.

  • ↵1-f Significantly less than air.