Potencies of tropanes at biogenic amine transporters
| Transporter | Drug | ||
|---|---|---|---|
| Cocaine | RTI-55 | PTT | |
| Uptake IC50(nM) | |||
| Dopamine | 150 | 3.2 | |
| Serotonin | 480 | 488 | |
| Norepinephrine | 126 | 3.3 | |
| Binding IC50(nM) | |||
| Dopamine | 173 | 1.3 | 8.2 |
| Serotonin | 302 | 0.4 | 131 |
| Norepinephrine | 404 | 16.4 | 65 |
Values listed are from Bennett et al. (1995) and Boja et al. (1991). Values for PTT refer to the racemic mixture.