Pharmacokinetic parameter estimates of (−)-M1
| Parameter | Estimate | IIV |
|---|---|---|
| V c(1) (l) | 0.255 (0.23) | 0.58 (0.67) |
| V c(2) (l) | 0.05 (0.18) | |
| V SS (l) | 0.72 (0.07) | NE |
| Cld (l/min) | 0.036 (0.14) | NE |
| Cl(1) (l/min) | 0.0395 (0.07) | 0.84 (0.47) |
| Cl(2) (l/min) | 0.0156 (0.05) |
Estimates of interindividual variability are expressed as c.v. (%). Precision of the estimates is expressed as relative standard error in parentheses. Relative standard error is standard error divided by the parameter estimate.
(1) and (2) refer to 2- and 8-mg/kg doses, respectively.Vc, initial volume of distribution;VSS, apparent volume of distribution at steady state; Cld, intercompartmental clearance; IIV, interindividual variability; NE, not estimated in the model.