Pharmacokinetic parameter estimates of (+)-M1
| Parameter | Estimate | IIV |
|---|---|---|
| V c(l) | 0.100 (0.33) | 55 (0.65) |
| V SS(l) | 0.781 (0.08) | NE |
| Cld (l/min) | 0.0563 (0.12) | NE |
| Cl = Cl1 · exp(−Cl2 · time) (l/min) | Cl1 = 0.035 (0.07) | 23 (0.42) |
| Cl2 = 0.0023 (0.17) |
Estimates of interindividual variability are expressed as c.v. (%). Precision of the estimates is expressed as relative standard error in parentheses. Relative standard error is standard error divided by the parameter estimate.
Vc, initial volume of distribution;VSS, apparent volume of distribution at steady state; Cld, intercompartmental clearance; IIV, interindividual variability; NE, not estimated in the model.