Phosphorylated metabolites as determined by 31P NMR
| Control | Cirrhotic | |||
|---|---|---|---|---|
| Normoxic | Hyperoxic | |||
| (n = 15) | (n = 6) | (n = 11) | (n = 6) | |
| Compound (μmol/g liver) | ||||
| ATP | 2.48 ± 0.39 | 2.84 ± 0.26 | 1.22 ± 0.283-b | 1.94 ± 0.473-a , 3-b |
| ADP | 0.97 ± 0.24 | 0.89 ± 0.13 | 0.74 ± 0.233-b | 0.77 ± 0.12 |
| Pi | 3.80 ± 0.83 | 3.00 ± 0.59 | 3.25 ± 0.85 | 2.98 ± 0.26 |
| ATP/ADP | 2.47 ± 0.45 | 3.47 ± 0.753-a | 1.73 ± 0.353-b | 2.56 ± 0.543-a , 3-b |
| Pi/ATP | 1.56 ± 0.26 | 1.12 ± 0.33 | 2.74 ± 0.483-b | 1.68 ± 0.363-a |
| Total phosphorus content | 26.47 ± 4.66 | 25.35 ± 1.57 | 16.05 ± 3.393-b | 19.87 ± 3.013-c |
| Compound (% total phosphorus content) | ||||
| ATP | 9.35 ± 0.88 | 11.15 ± 0.923-a | 7.65 ± 0.813-b | 9.51 ± 0.933-a , 3-b |
| ADP | 3.68 ± 0.71 | 3.59 ± 0.53 | 4.58 ± 0.71 | 3.86 ± 0.49 |
| Pi | 14.26 ± 1.66 | 12.29 ± 2.47 | 20.23 ± 2.943-b | 15.37 ± 2.043-a |
| PE | 1.36 ± 0.22 | 1.88 ± 0.24 | 2.49 ± 0.663-b | 2.92 ± 0.583-c |
| GPE | 6.07 ± 0.79 | 5.55 ± 0.46 | 3.95 ± 1.623-b | 5.06 ± 0.77 |
| NAD | 14.62 ± 1.35 | 13.84 ± 0.90 | 9.31 ± 2.273-b | 11.38 ± 1.173-c |
| PME | 24.78 ± 3.29 | 21.28 ± 2.66 | 30.98 ± 5.193-b | 23.50 ± 3.453-a |
| PDE | 9.85 ± 1.69 | 9.45 ± 0.79 | 7.15 ± 2.95 | 9.17 ± 0.55 |
| PME/PDE | 2.44 ± 0.51 | 2.28 ± 0.43 | 5.39 ± 2.813-b | 2.47 ± 0.573-a |
Normoxic-treated rats were exposed to room air. Hyperoxic-treated rats were exposed to a continuous flow of 95% O2, 5% CO2for 1 h.