NO Prodrug | MAP | ICP | CPP | Average CBF Ipsilateral Forebrain | CVR |
---|---|---|---|---|---|
mm Hg | ml/min/g | mm ml/min/g | |||
Control | |||||
Saline | 80.7 ± 8.01 | 5.54 ± 1.04 | 75.1 ± 5.08 | 0.89 ± 0.09 | 102 ± 17.8 |
Thionitrite (NO·, NO−, NO+) | |||||
SNAP-CDfem (1.7 mmol/min) | 64.7 ± 9.43 | 5.11 ± 1.09 | 59.6 ± 10.4 | 1.02 ± 0.05 | 61.3 ± 7.15 |
SNAP-CDcbv (1.7 mmol/min) | 68.8 ± 1.00 | 5.71 ± 1.45 | 62.3 ± 1.99 | 0.91 ± 0.06 | 76.9 ± 9.84 |
Nitroxyl agents (NO·, NO−) | |||||
Angeli's Salt | 64.3 ± 9.31 | 8.17 ± 0.39 | 56.2 ± 9.47 | 0.78 ± 0.07 | 87.4 ± 21.3 |
Diazeniumdiolates (NO·) (i.e. NONOates) | |||||
MAHMA NONOate | 50.8 ± 10.4 | 3.61 ± 0.23 | 47.2 ± 10.5 | 0.89 ± 0.08 | 60.3 ± 13.9 |
Spermine NONOate | 40.4 ± 2.83 | 5.73 ± 0.81 | 36.0 ± 4.07 | 0.77 ± 0.07 | 49.5 ± 6.41 |
DETA NONOate | 65.8 ± 13.3 | 8.77 ± 1.43 | 57.0 ± 14.5 | 0.95 ± 0.07 | 68.6 ± 10.7 |
Data are mean ± S.E. of three to six rats. Statistical significance was assessed by one-way ANOVA with Newman-Keuls post hoc test. Although there are trends in the data, these trends are not statistically significant.
cbv, cerebrovascular administration via the external carotid artery; fem, systemic administration via the femoral artery; SP, systolic pressure.