Table 1

Apparent permeability coefficient (Papp [cm/s] × 10−6) from the initial basal-to-apical and apical-to-basal transport rates at substrate concentrations of 5 μM

Caco-2L-MDR1LLC-PK1
Papp [basal-apical]Papp [apical-basal]Papp [basal-apical]Papp [apical-basal]Papp [basal-apical]Papp [apical-basal]
Verapamil11.9  ± 1.312.9  ± 6.427.8  ± 3.118.8  ± 0.71-150 22.1  ± 624.0  ± 15.3
Norverapamil9.4  ± 1.86.3  ± 7.118.9  ± 4.82.2  ± 0.41-150 8.6  ± 0.69.3  ± 6.6
D-7033.6  ± 1.14.8  ± 0.23.8  ± 2.12.3  ± 0.66.1  ± 0.34.4  ± 1.4
D-61718.5  ± 4.51.6  ± 0.61-150 23.0  ± 4.60.2  ± 0.41-150 1.0  ± 0.50.9  ± 0.5
D-62017.7  ± 5.02.6  ± 0.61-150 19.5  ± 6.20.4  ± 0.51-160 4.9  ± 2.58.0  ± 7.3
  • 1-150P < .05,Papp [basal-apical] versusPapp [apical-basal].

  • 1-160P < .01, Papp [basal-apical]versus Papp [apical-basal].