Binding parameters with HEK.EBNA[Human SUR1] cell membranes
| Compound | IC50 | Ki | Hill Coefficient |
|---|---|---|---|
| nM ± S.E.M.2-a | nM ± S.E.M. | Slope ± S.E.M. | |
| Glibenclamide | 4.8 ± 0.8 | 2.3 ± 0.4 | 1.0 ± 0.05 |
| Glimepiride | 9.6 ± 1.9 | 4.5 ± 0.9 | 1.1 ± 0.13 |
| Glipizide | 220 ± 50 | 100 ± 24 | 0.82 ± 0.12 |
| Repaglinide | 500 ± 80 | 240 ± 38 | 0.90 ± 0.07 |
| Nateglinide | 2,800 ± 240 | 1,300 ± 110 | 0.92 ± 0.03 |
| l-Isomer of nateglinide | 40,000 ± 6,000 | 19,000 ± 2,800 | 0.80 ± 0.05 |
| Tolbutamide | 570,000 ± 36,000 | 270,000 ± 17,000 | 1.05 ± 0.09 |
↵2-a Values determined from three separate experiments.